Q:  I was wondering if uncontrolled or high blood sugar could cause a depressive episode or mixed episodes?


Dear Karla --
I hadn't heard of this so did a search (PUB MED, entered "hyperglycemia depression") and sure enough, one article notes that "Diabetes doubles the risk for depression" ^Rubin.     As for a mixed episode, to the extent that this is actually different than a depressed episode, i.e. more than the depression underneath worsening, just as in unipolar depression as Rubin et al reported, I couldn't find references about this (it gets lost in the noise about medications that worsen glucose control, a big-money issue right now in the fight between companies whose medications do this and those that don't). 

Dr. Phelps

Published September, 2004